Jarrow Formulas SAMe Tablets, 400mg, 30ct Box Jarrow Formulas SAMe Tablets, 400mg, 60ct Box

400 mg / 30-60 Enteric-Coated Tablets / 1-2 Months Supply

Jarrow Formulas® SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

With More of the Biologically Active S,S than R,S Form
Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas® SAMe is made naturally by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe.

SAMe supports:

Brain Metabolism and Mood*
SAMe methylation reactions are involved in the synthesis of
phosphatidylcholine, a substantial constituent of grey matter within the
brain and cellular membranes.* It has also been proposed to be involved
in the formation or metabolism of neurotransmitters, which helps to
support a balanced mood.*

Joint Health*
SAMe supports the production of healthy connective tissue through
transsulfuration.* In this transsulfuration process, critical components
of connective tissue known as glycosaminoglycans (GAGs), including
glucosamine and chondroitin, are sulfated by SAMe metabolites to
yield sulfated GAGs, such as glucosamine sulfate and chondroitin
sulfate, the building blocks of cartilage.*

Liver Function*
SAMe supports the synthesis of glutathione (GSH), which is
critical for antioxidant defenses and liver functions including phase
II detoxification.*


Gluten Free
Serving Size: 1 Tablet

Amount Per Serving


S-Adenosyl Methionine (from 800 mg of SAMe Tosylate Disulfate)

† Daily Value (DV) not established.

Other Ingredients: Microcrystalline cellulose, coating (hypromellose acetate succinate, stearic acid [vegetable source], triethyl citrate and riboflavin), glyceryl behenate, magnesium stearate (vegetable
source), silicon dioxide, mannitol and sodium starch glycolate.

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.

EnteroGuard® is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.

About SAMe - 400mg

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  • Supports: Joint Health*, Brain Metabolism and Mood*, Liver Function*
  • Enteric-Coated
  • 68-80% Active S,S Form
  • Made Naturally By Fermentation
  • Individually Blister-Packed
  • Suggested Use

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    Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.

    WARNING: Do not use if pregnant or nursing. Individuals with Parkinson’s disease, bi-polar disorder, or manic depression should not use this product. May cause gastrointestinal
    upset in some persons. Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin
    re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.


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    Superior Science

    Our staff of scientists leverage expertise from researchers and institutions worldwide who study products and ingredients, and how they work with your body. By supporting scientific research and funding studies, Jarrow Formulas® maintains superior science as the guiding principle in all it does.

    Smarter Formulas

    Our formulations are carefully crafted and informed by strong scientific research. Jarrow Formulas’ products therefore have the potential to support and promote optimal health.

    Quality Ingredients

    Our customers can be assured of both purity and potency in every Jarrow Formulas product. We evaluate the purity, strength and composition of all ingredients and only work with raw material suppliers that follow the same Current Good Manufacturing Practices (cGMP) we do.


    Our Science

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